SE448877B - Karbostyrilforeningar, farmaceutiska kompositioner innehallande dessa och forfaranden for framstellning derav - Google Patents

Karbostyrilforeningar, farmaceutiska kompositioner innehallande dessa och forfaranden for framstellning derav

Info

Publication number
SE448877B
SE448877B SE8106430A SE8106430A SE448877B SE 448877 B SE448877 B SE 448877B SE 8106430 A SE8106430 A SE 8106430A SE 8106430 A SE8106430 A SE 8106430A SE 448877 B SE448877 B SE 448877B
Authority
SE
Sweden
Prior art keywords
group
formula
piperazinyl
compound
dihydrocarbostyril
Prior art date
Application number
SE8106430A
Other languages
English (en)
Swedish (sv)
Other versions
SE8106430L (sv
Inventor
M Tominaga
Y Yang
H Ogawa
K Nakagawa
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of SE8106430L publication Critical patent/SE8106430L/xx
Publication of SE448877B publication Critical patent/SE448877B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
SE8106430A 1980-10-31 1981-10-30 Karbostyrilforeningar, farmaceutiska kompositioner innehallande dessa och forfaranden for framstellning derav SE448877B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55154071A JPS5777676A (en) 1980-10-31 1980-10-31 Carbostyril derivative

Publications (2)

Publication Number Publication Date
SE8106430L SE8106430L (sv) 1982-05-01
SE448877B true SE448877B (sv) 1987-03-23

Family

ID=15576252

Family Applications (2)

Application Number Title Priority Date Filing Date
SE8106430A SE448877B (sv) 1980-10-31 1981-10-30 Karbostyrilforeningar, farmaceutiska kompositioner innehallande dessa och forfaranden for framstellning derav
SE8406209A SE466655B (sv) 1980-10-31 1984-12-06 Karboxylsyrafoereningar samt foerfarande foer framstaellning daerav

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8406209A SE466655B (sv) 1980-10-31 1984-12-06 Karboxylsyrafoereningar samt foerfarande foer framstaellning daerav

Country Status (24)

Country Link
US (1) US4415572A (en])
JP (1) JPS5777676A (en])
KR (1) KR860001944B1 (en])
AR (2) AR242563A1 (en])
AT (1) AT381701B (en])
AU (1) AU524419B2 (en])
BE (1) BE890942A (en])
CA (1) CA1209575A (en])
CH (2) CH656616A5 (en])
DE (2) DE3153260C2 (en])
DK (1) DK155665C (en])
ES (3) ES8306743A1 (en])
FI (1) FI77450C (en])
FR (2) FR2493320B1 (en])
GB (1) GB2086896B (en])
IT (2) IT1210585B (en])
MX (1) MX8481A (en])
NL (2) NL194205C (en])
NO (1) NO158099C (en])
PH (1) PH17962A (en])
PT (1) PT73910B (en])
SE (2) SE448877B (en])
SU (1) SU1426452A3 (en])
ZA (1) ZA817515B (en])

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JPS5883677A (ja) * 1981-11-11 1983-05-19 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
JPS5929667A (ja) * 1982-08-13 1984-02-16 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体および強心剤
CH655110A5 (de) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
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JPS60126270A (ja) * 1983-12-14 1985-07-05 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
PT79699B (en) * 1983-12-22 1986-12-10 Pfizer Process for preparing quinolone inotropic agents
US4774246A (en) * 1984-01-26 1988-09-27 Abbott Laboratories Quinoline antibacterial compounds
NZ212209A (en) * 1984-05-29 1988-08-30 Pfizer Quinolone derivatives and pharmaceutical compositions
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JPS61145162A (ja) * 1984-12-19 1986-07-02 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
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GB8630702D0 (en) * 1986-12-23 1987-02-04 Wellcome Found Quinoline compound
US5166160A (en) * 1986-12-23 1992-11-24 Burroughs Wellcome Co. Quinoline compound
JPS63225357A (ja) * 1987-03-12 1988-09-20 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
GB8827189D0 (en) * 1988-11-21 1988-12-29 Fujisawa Pharmaceutical Co 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same
EP0552373B1 (en) * 1991-07-03 1999-10-13 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulator
US5750529A (en) * 1991-07-03 1998-05-12 Otsuka Pharmaceutical Co., Ltd. Apoptosis regulating compostion
WO1993011769A1 (en) * 1991-12-10 1993-06-24 Otsuka Pharmaceutical Co., Ltd Carcinostatic
JP2686887B2 (ja) * 1992-08-11 1997-12-08 キッセイ薬品工業株式会社 ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
CA2121148A1 (en) * 1992-08-19 1994-03-03 Satoru Nakai Apoptosis regulator
JP2826790B2 (ja) * 1992-12-26 1998-11-18 キッセイ薬品工業株式会社 ３，４−ジヒドロカルボスチリル誘導体
KR0185226B1 (ko) * 1993-03-02 1999-05-01 오오쓰까 아끼히꼬 이식 조직의 거부반응 억제제 및 il-1 생산 억제제
JPH0733664A (ja) * 1993-07-26 1995-02-03 Otsuka Pharmaceut Co Ltd 平滑筋細胞増殖抑制剤
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US5504093A (en) * 1994-08-01 1996-04-02 Otsuka Pharmaceutical Co., Ltd. Method for inhibiting nucleoside and nucleobase transport in mammalian cells, and method for inhibition of DNA virus replication
PT889889E (pt) * 1996-03-29 2007-01-31 Duphar Int Res Composto de piperazina e piperidina
GB2312843A (en) * 1996-05-07 1997-11-12 Merck & Co Inc Method of treating rheumatoid arthritis
US5684007A (en) * 1996-09-05 1997-11-04 Otsuka Pharmaceutical Co., Ltd. Methods for inhibiting cardiac fibroblast growth and cardiac fibrosis
CA2378298A1 (en) 1999-08-27 2001-03-08 Lawrence G. Hamann 8-substituted-6-trifluoromethyl-9-pyrido¬3,2-g|quinoline compounds as androgen receptor modulators
US6566372B1 (en) * 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
IL148045A0 (en) * 1999-08-27 2002-09-12 Ligand Pharm Inc Androgen receptor modulator compounds and methods
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ES2393885T7 (es) 2007-06-04 2014-01-30 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
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US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
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JPS6017072B2 (ja) * 1978-09-05 1985-04-30 三菱電機株式会社 赤熱金属検出器
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Also Published As

Publication number Publication date
AU7699681A (en) 1982-05-06
AR242375A1 (es) 1993-03-31
IT1210585B (it) 1989-09-14
DK480381A (da) 1982-05-01
JPS5777676A (en) 1982-05-15
SE8106430L (sv) 1982-05-01
SU1426452A3 (ru) 1988-09-23
ES507198A0 (es) 1983-06-16
GB2086896A (en) 1982-05-19
NO158099B (no) 1988-04-05
ES520637A0 (es) 1984-04-16
PT73910B (en) 1983-04-18
NL194205C (nl) 2001-09-04
ES8306743A1 (es) 1983-06-16
ZA817515B (en) 1982-10-27
AR242563A1 (es) 1993-04-30
IT1226479B (it) 1991-01-16
NL8403096A (nl) 1985-02-01
IT8547867A0 (it) 1985-03-26
FI813408L (fi) 1982-05-01
DE3142982C2 (de) 1985-12-19
FI77450B (fi) 1988-11-30
NO158099C (no) 1988-07-13
NO813678L (no) 1982-05-03
IT8149588A0 (it) 1981-10-29
AT381701B (de) 1986-11-25
SE8406209L (sv) 1984-12-06
FR2552760A1 (fr) 1985-04-05
FI77450C (fi) 1989-03-10
KR860001944B1 (ko) 1986-11-01
GB2086896B (en) 1984-10-10
JPH0143747B2 (en]) 1989-09-22
CA1209575A (en) 1986-08-12
DK155665C (da) 1989-09-04
DK155665B (da) 1989-05-01
ES8403886A1 (es) 1984-04-16
SE8406209D0 (sv) 1984-12-06
DE3153260C2 (en]) 1989-05-24
ATA460281A (de) 1986-04-15
CH650782A5 (de) 1985-08-15
ES520638A0 (es) 1984-04-16
CH656616A5 (de) 1986-07-15
ES8403885A1 (es) 1984-04-16
PT73910A (en) 1981-11-01
FR2493320A1 (fr) 1982-05-07
MX8481A (es) 1994-02-28
DE3142982A1 (de) 1982-06-24
SE466655B (sv) 1992-03-16
FR2552760B1 (fr) 1988-08-05
NL194205B (nl) 2001-05-01
AU524419B2 (en) 1982-09-16
BE890942A (fr) 1982-02-15
FR2493320B1 (fr) 1985-08-23
DE3153260A1 (en]) 1985-05-15
NL8104923A (nl) 1982-05-17
KR830007607A (ko) 1983-11-04
PH17962A (en) 1985-02-20
US4415572A (en) 1983-11-15

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